1mg finasterida


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I do not think the dose is highly correlated with side effects, although it tends to exist.

For example, 5 mg / day decreased prostate mass by more than 1 mg / day at 6 months, although they are virtually similar in effectiveness.

This leads me to believe that higher doses would only increase the risk of complications in people prone to side effects. If you had side effects at 300 mg / day, you would probably still have them at almost any other dose. Initial clinical trials for finasteride had subjects ingesting up to 100 mg / day for one week with no reported side effects after discontinuation, while about 2–5% experienced side effects during the study.

The blood concentration of finasteride is of little significance as a 1 mg dose produces almost the same result during peak concentrations after a single 100 mg dose. The only advantage of a 100 mg dose is a more sustained concentration of finasteride in the blood, which would take about 60 hours for the serum concentration to reach the same levels as 1 mg within 24 hours. For obvious reasons, this is not a cost effective method for medication. In addition, finasteride blood concentrations reach a steady state after daily administration in about 4 days, with the maximum concentration no longer increasing. This is true for any dose.

For example, taking 100 mg / day would give you a maximum peak concentration comparable to a single dose of 106.6 mg, assuming the half-life chemical metabolism is 6 hours. For 1 mg / day is 1.06 mg, for 0.5 mg / day is 0.533. What this means is that as long as you can take doses at least half-life (every 6 hours), and not before then, then the maximum potential for serum finasteride concentrations is double that dose.

You can see that the fall is exponential as by nature of the 6 hour half life. No accumulation of finasteride occurs as a result. Usually, how much finasteride you take and how often you take it is irrelevant on a large scale. Seeing how effective it can be from doses as low as 0.12 mg, and being a suicide inhibitor, it takes some time to regenerate 5αr-II enzymes, probably at least 72 hours to have any significant change in serum DHT, given the half-life of 5αr-II was suggested to be 7 to 14 days. Although tissue DHT concentrations, which is the most important principle here, may be earlier than that. With that said, I'm assuming that a large dose every 72 hours with at least 1.25mg or 0.5-1mg EOD or 0.25-0.5 ED should give results that are quite similar, and almost as effective as the most ideal doses.

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